Crystalline Pharmaceutical and Methods of Preparation and Use Thereof

摘要

Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this invention.;

主权项

1. A method of synthesizing a compound of Formula I: comprising the steps: a) base hydrolysis of Formula AA with a base in an aprotic solvent: wherein R is a carbon containing moiety; and b) isolating a compound of Formula I.