发明名称 Calcilytic Compounds
摘要 Novel calcilytic compounds and methods of using them are provided.
申请公布号 US2015183723(A1) 申请公布日期 2015.07.02
申请号 US201514640711 申请日期 2015.03.06
申请人 GlaxoSmithKline, LLC 发明人 MARQUIS Robert W.;Casillas Linda N.;Ramanjulu Joshi M.;Callahan James Francis
分类号 C07C217/54 主分类号 C07C217/54
代理机构 代理人
主权项 1. A method of treating a disease or disorder characterized by abnormal bone or mineral homeostasis, which comprises the administration to a subject in need of treatment thereof an effective amount of a compound of formula (I):wherein: R1 and R5 are independently selected from the group consisting of H and halogen; R2, R3 and R4 are independently selected from the group consisting of H, halogen and J-K wherein: J is a covalent bond, alkylene or alkenyl; and K is selected from the group of CO2R8, wherein R8 is H or alkyl; R6 is selected from the group consisting of H and alkyl; and R7 is selected from the group consisting of aryl, fused aryl, dihydro, tetrahydro fused aryl, and heteroaryl, unsubstituted or substituted with any substituent selected from the group consisting of OH, halogen, C1-4 alkyl, C1-4alkoxy, C3-6 cycloalkyl, CF3, OCF3, CN and NO2,or a pharmaceutically acceptable salt or complex thereof.
地址 Wilmington DE US