| 主权项 |
1. A method of treating a nicotine addiction comprising: administrating to a patient in need thereof a therapeutically effective amount of a compound of the formula wherein: Z is O or NRa where Ra is hydrogen or C1-6 alkyl; R1 is a ring of the formula (a)-(h) below: R2 is hydrogen, C1-6 alkyl, or C1-6 haloalkyl; each R3 is independently hydrogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, or halo and can be present on any carbon atom in the rings; R4 is pyridinyl or pyrazolyl each optionally substituted with one or two substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkoxy, cyano, or halo; all of X1, X2, X3, and X4 are CR5 or one of X1, X2, X3, and X4 is N and the others are CR5; each R5 is independently hydrogen, C1-6 alkyl, halo, hydroxy, or cyano provided that at least one of R5 is hydrogen; X5 is N or CR6 where R6 is hydrogen, C1-6 alkyl, or halo; or a pharmaceutically acceptable salt thereof or N-oxide thereof. |
