发明名称 |
GLUCOCEREBROSIDASE MODULATORS AND USES THEREOF |
摘要 |
The invention provides isofogamine analogs of structural formula (I) below that modulate and stabilize glucocerebrosidases and enhance their enzymatic activity in vivo. Such compounds, prodrugs and compositions thereof are useful in treating synucleinopathy, lysosomal storage disease and relevant neurodegenerative disease. |
申请公布号 |
WO2015095963(A1) |
申请公布日期 |
2015.07.02 |
申请号 |
WO2014CA51252 |
申请日期 |
2014.12.22 |
申请人 |
ALECTOS THERAPEUTICS INC. |
发明人 |
KAUL, RAMESH;MCEACHERN, ERNEST J.;SUN, JIANYU;VOCADLO, DAVID J.;ZHOU, YUANXI;ZHU, YONGBAO |
分类号 |
C07D221/20;A61K31/438;A61P25/00;A61P25/16 |
主分类号 |
C07D221/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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