TRACKING OF TUMOR LOCATION FOR TARGETED RADIATION TREATMENT

摘要

Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. Functional models can be used to accurately obtain a location of specific tissue using sensors at identifiable locations of the patient's body. Using the relative distances between the identifiable sensor locations can allow a patient to be in various positions. The functional models can be prepared using accurate pre-treatment scans, which can be taken at various body positions (e.g., rotations and/or translations). The trajectory of the beam can be measured efficiently and accurately using beam sensors attached to a beam assembly, where a model maps the beam sensor locations to a trajectory of the beam. Further, a motion model can use measurements made during treatment to obtain a time-dependent functions of the movement of the specific tissue, the change of an optimal beam trajectory over time, or the change in input commands to a beam positioner.

主权项

1. A system for directing a radiation beam to a location of diseased tissue of a patient, the system comprising:
a beam assembly configured to emit a directed radiation beam; one or more detectors configured to receive a signal from at least one sensor that indicates motion of the patient; one or more processors that are in communication with the beam assembly and the one or more detectors and that are configured to:
predict a plurality of locations of the diseased tissue relative to a reference location using the at least one sensor, each predicted location corresponding to a different time during treatment with the radiation beam;based on the plurality of locations, determine one or more parameters for a time-dependent predictive motion model that accounts for a predicted motion of the diseased tissue relative to the beam assembly;use the motion model to calculate a trajectory for the radiation beam; andadjust the beam assembly such that the radiation beam follows the calculated trajectory.