| 发明名称 |
FUSION PROTEIN CAPABLE OF BINDING VEGF-A AND TNF-ALPHA |
| 摘要 |
The present application describes an isolated nucleic acid molecule encoding a polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) a nucleotide sequence encoding a TNFR2 component and VEGFR1 component operatively linked to (b) a nucleotide sequence encoding a multimerizing component, wherein the TNFR2 component consists essentially of a nucleotide sequence encoding the amino acid sequences of cystein rich domain 1, cystein rich domain 2, cystein rich domain 3, and cystein rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component consists essentially of a nucleotide sequence encoding the amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1. |
| 申请公布号 |
US2015183864(A1) |
申请公布日期 |
2015.07.02 |
| 申请号 |
US201414539447 |
申请日期 |
2014.11.12 |
| 申请人 |
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KAIST) |
发明人 |
JUNG KEEHOON;KOH YOUNG JUN;LEE GYUN MIN;KIM SUN CHANG;KOH GOU YOUNG |
| 分类号 |
C07K16/24;C07K16/22 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion polypeptide capable of synchronously binding VEGF polypeptide and TNF polypeptide comprising: (a) TNFR2 component and VEGFR1 component operatively linked to (b) a multimerizing component, wherein the TNFR2 component comprising amino acid sequences of cysteine rich domain 1, cysteine rich domain 2, cysteine rich domain 3, or cysteine rich domain 4 of the extracellular domain of TNFR2, and wherein the VEGFR1 component comprises amino acid sequences of Ig-like domain 2 of the extracellular domain of VEGFR1. |
| 地址 |
DAEJEON KR |
