REGIMENS FOR TREATMENTS USING ANTI-IGF ANTIBODIES

摘要

Without limitation, this disclosure relates to methods of treating cell proliferation disorders, neoplastic disorders, cancers, tumors and the like using anti-IGF antibodies, or antigen binding fragments thereof. Disclosed herein are methods of treating cancer in a patient, for example a human patient, comprising administering to the patient at least two doses of an antibody which binds both IGF-I and/or IGF-II. The doses are separated by about a week, or by about three weeks, and each dose comprises an amount of antibody greater than about 0.5 mg kg of patient body mass and less than about 50 mg per kg of patient body mass.

主权项

1. A method of treating cancer in a patient, said method comprising administering to the patient at least two doses of an antibody, or antigen binding fragment thereof, which binds IGF-I and IGF-II, wherein doses are separated by about a week, and wherein each dose is between about 1.5 mg per kg of body mass and about 15 mg per mg per kg of body mass.