发明名称 |
Repertoire of allo-restricted peptide-specific T cell receptor sequences and use thereof |
摘要 |
The present invention is directed to a kit-of-parts or composition containing nucleic acid sequences coding for high-avidity, allo-restricted TCR, wherein the TCR are independently directed against the tyrosinase antigen, the melan-A antigen and the survivin antigen. The invention is further directed to a kit-of-parts or composition containing at least three groups of transgenic lymphocytes transformed with vectors coding for TCR against said antigens. Furthermore, the present invention provides a pharmaceutical composition and its use in the treatment of diseases involving malignant cells expressing said tumor-associated antigens. The invention further relates to a nucleic acid molecule coding for a TCR that recognizes the survivin antigen, a TCR encoded thereby and a T cell expressing said TCR. Further, the invention discloses a vector, a cell and a pharmaceutical composition encoding/containing same and their use in the treatment of diseases involving malignant cells expressing survivin. |
申请公布号 |
AU2010210083(B2) |
申请公布日期 |
2015.07.02 |
申请号 |
AU20100210083 |
申请日期 |
2010.02.09 |
申请人 |
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT (GMBH);MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN |
发明人 |
SCHENDEL, DOLORES J.;WILDE, SUSANNE;FRANKENBERGER, BERNHARD;UCKERT, WOLFGANG |
分类号 |
C12N15/12;A61K35/26;A61P35/00;C07K14/705;C07K14/725;C07K14/74 |
主分类号 |
C12N15/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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