USE OF PEDF-DERIVED POLYPEPTIDES FOR PROMOTING STEM CELLS PROLIFERATION AND WOUND HEALING

摘要

Disclosed herein is a synthetic peptide, which has an amino acid sequence that has 20-39 amino acid residues. The synthetic peptide has at least 80% amino acid sequence identity to SEQ ID NO: 1, and includes at least 20 consecutive residues that has at least 90% amino acid sequence identity to residues 11-30 of SEQ ID NO: 1. Also disclosed herein are compositions containing the synthetic peptide and applications thereof. According to various embodiments of the present disclosure, the synthetic peptide is useful in promoting stem cells proliferation or wound healing.

主权项

1. A synthetic peptide for promoting the proliferation of limbal epithelial stem cells or hair follicle stem cells, consisting of an amino acid sequence having 20-39 amino acid residues in length and at least 80% amino acid sequence identity to SEQ ID NO: 1, wherein the amino acid sequence comprises at least 20 consecutive residues identical to residues 11-30 of SEQ ID NO: 1.