| 摘要 |
A heteroaromatic methyl cyclic amine derivative represented by formula (IA) or a pharmaceutically acceptable salt thereof is useful for treatment or prophylaxis of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's disease, eating disorder, cephalalgia, hemicrania, pain, digestive diseases, epilepsy, inflammation, immune-related diseases, endocrine-related diseases and hypertension, on the basis of an orexin (OX) receptor antagonist activity.; |
| 主权项 |
1. A compound represented by formula (IA): wherein, X1 and X2 are the same or different and represent a nitrogen atom or formula CH; Y represents any of the structures in the following formula group (a): n represents 1 or 2; R1 represents a hydrogen atom, a halogen atom or a C1-6 alkyl group; R2 represents a triazolyl group, a pyridyl group or a pyrimidinyl group; R3 represents a hydrogen atom, a halogen atom or a C1-6 alkyl group, wherein the C1-6 alkyl group may optionally be substituted with 1 to 3 halogen atoms; and R4 represents a hydrogen atom or a C1-6 alkyl group; or a pharmaceutically acceptable salt thereof. |
