ANTI-INTERLEUKIN-1 (IL-1) ANTIBODY USED AS A TARGETING AGENT TO TREAT ARTHRITIS AND OTHER DISEASES

摘要

This invention describes the use of anti-IL-1 antibody as a targeting agent attached to liposomes incorporating anti-inflammatory drugs to treat arthritis and other inflammatory diseases. A variety of steroidal and non-steroidal drugs and disease modifying drugs and other anti-inflammatory compounds may be incorporated into the anti-IL-1 antibody coated liposomes. The anti-IL-1 antibody coated drug liposomes will accumulate within the inflamed site where the drug is released for maximum therapeutic effect. Other nanosized drug delivery vehicles such as dendrimers, micelles, nanocapsules and nanoparticles may be similarly coated with anti-IL-1 antibody and used to deliver the drug to the site of inflammation. Also in lieu of the anti-IL-1 antibody other IL-1 binding agents such as anti-IL-1 aptamers and anti-IL-1 binding peptides may be used to coat various nanosized drug delivery vehicles in order to deliver the drug to the site of inflammation.

主权项

1. A means of treating rheumatoid arthritis and other inflammatory disorders using anti-interleukin 1 (IL-1) antibody to deliver anti-inflammatory drugs to the site of inflammation by a) encapsulating or incorporating the anti-inflammatory drug into nanosized delivery vehicles such as liposomes, micelles, dendrimers, nanocapsules, nanoparticles and other nanosized drug delivery vehicles and b) attaching an anti-IL-1 antibody to the exterior surface of said nanosized delivery vehicle.