| 摘要 |
A device for application to the skin of a patient to facilitate intravenous access (e.g. via needles, syringes, cannulas or catheters) comprises an upper surface and a lower surface; the lower surface being suitable for contacting the skin of the patient at the location of a vein to be accessed. The device further includes a heat patch, an organic nitrate vasodilator agent of glyceryl trinitrate and an amino based anaesthetic agent which is an amino ester or amino amide. In use the device is activated by the application of pressure to the patch so as to initiate an exothermic chemical reaction (for example by crystallization of a supercooled aqueous salt or sodium acetate solution) in the heat patch which heats the patch to a temperature of from 50 to 55°C for a period of at least one minute. When the device is applied to the skin of the patient, with the lower surface contacting the skin of the patient, the vasodilator agent and the anaesthetic agent are released from the lower side of the device onto the patient's skin at the location of a vein to be accessed. |
