发明名称 |
ENGINEERED ANTHRAX LETHAL TOXIN FOR TARGETED DELIVERY |
摘要 |
The present invention provides methods and systems for targeted delivery of a compound to a target cell that overexpresses two different proteinases. Specifically, two different modified protective antigen proteins, each comprising a cleavage site recognized by a distinct proteinase in place of the native proteinase cleavage site recognized by furin, are administered in combination with a compound that contains a protective antigen binding site. Upon cleavage by the two proteinases the two modified protective antigen proteins form a hetero-oligomer, allowing the compound to bind to the hetero-oligomer and subsequently to be translocated into the target cell. |
申请公布号 |
EP2887966(A1) |
申请公布日期 |
2015.07.01 |
申请号 |
EP20130792777 |
申请日期 |
2013.08.22 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA ASREPRESENTED BY THE SECRETARY OF THE DEPARTMENT OFHEALTH AND HUMAN SERVICES |
发明人 |
LEYSATH, CLINTON EDWARD;LEPPLA, STEPHEN H.;PHILLIPS, DAMILOLA DANIEL |
分类号 |
A61K47/48;B82Y5/00;C07K14/32 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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