制造ＪＡＫ抑制剂之方法及相关中间化合物;PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS

摘要

本发明系关于制备式III对掌性取代之吡唑基吡咯并[2,3-d]嘧啶类及相关合成中间化合物之方法。此对掌性取代之吡唑基吡咯并[2,3-d]嘧啶类可作为蛋白质酪胺酸激酶(JAK)之Janus激酶族群之抑制剂用于治疗炎性疾病、骨髓增生病症及其他疾病。;The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.