ANTITRICHOPHYTOSIS SOLUTION FOR EXTERNAL USE

摘要

According to the present invention, a topical liquid agent having antifungal activity against dermatophytes, and further high nail permeability can be provided. The topical liquid agent for nail and/or skin for prevention or treatment of dermatophytosis comprises a film-forming agent and a compound represented by the formula:
wherein R 1 represents a hydrogen atom, C 1-6 alkyl, or trifluoromethyl, R 2 represents a hydrogen atom, C 1-6 alkyl, halogen, -COO(C 1-6 alkyl), or (CH 2 ) 1-3 COOR where R represents a hydrogen atom or C 1-6 alkyl, R 3 represents a hydrogen atom, C 1-6 alkyl, amino, trifluoromethyl, or OR where R represents a hydrogen atom or C 1-6 alkyl, R 4 represents a hydroxyl group, R 5 represents a hydrogen atom, C 1-6 alkyl, a hydroxyl group, or halogen, R 6 represents a hydrogen atom, C 1-6 alkyl, trifluoromethyl, halogen, amino, -NR a R b , nitro, hydroxy-C 1-6 alkyl, -CONR a R b , -COO(C 1-6 alkyl), -COOH, -(CH 2 ) 1-3 COOR, or OR a where R represents a hydrogen atom or C 1-6 alkyl, R a and R b may be the same or different from each other, and each represent a hydrogen atom, C 1-6 alkyl, or C 1-6 acyl, R 7 represents a hydrogen atom, C 1-6 alkyl, -OR where R represents a hydrogen atom or C 1-6 alkyl, or halogen, R 8 represents a hydrogen atom, C 1-6 alkyl, a hydroxyl group, amino, or nitro,
or a salt thereof.