| 发明名称 | Antibody neutralizers of human granulocyte macrophage colony stimulating factor | ||
| 摘要 | The present invention relates to a human monoclonal antibody or fragment thereof which specifically binds to and neutralizes primate GM-CSF. | ||
| 申请公布号 | US9067993(B2) | 申请公布日期 | 2015.06.30 |
| 申请号 | US201113198558 | 申请日期 | 2011.08.04 |
| 申请人 | AMGEN RESEARCH (MUNICH) GMBH | 发明人 | Raum Tobias;Hepp Julia;Vieser Eva;Petsch Silke;Zeman Steven;Wolf Andreas;Bruckmaier Sandra |
| 分类号 | A61K39/395;C07K16/24;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Marshall, Gerstein & Borun LLP | 代理人 | Marshall, Gerstein & Borun LLP |
| 主权项 | 1. A human monoclonal antibody or fragment thereof which specifically binds to and neutralizes primate GM-CSF, comprising in its light chain variable region a CDR1 comprising an amino acid sequence as set out in SEQ ID NO: 16, a CDR2 comprising an amino acid sequence as set out in SEQ ID) NO: 17 and a CDR3comprising an amino acid sequence as set out in SEQ ID NO: 18; and comprising in its heavy chain variable region a CDR1 comprising an amino acid sequence as set out in SEQ ID NO: 14, a CDR2 comprising an amino acid sequence as set out in SEQ ID NO: 15 and a CDR3 comprising an amino acid sequence as set out in any of SEQ ID NOs: 1-13 or 56. | ||
| 地址 | Munich DE | ||