Methods of impairing osteoclast differentiation using antibodies that bind Siglec-15

摘要

This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are the isolation and identification of polynucleotides, polypeptides, variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes.

主权项

1. A method for inhibiting osteoclast differentiation in a mammal in need thereof, the method comprising administering a compound that inhibits osteoclast differentiation activity of SEQ ID NO.: 48, wherein the compound is an antibody or an antigen binding fragment thereof that binds to SEQ ID NO.: 48.