发明名称 1, 3-DIHYDROIMIDAZOLE-2-THIONE DERIVATIVES AS INHIBITORS OF DOPAMINE-BETA-HYDROXYLASE
摘要 <p>Compounds of formula I and a method for their preparation are described, where R1, R2 and R3 are the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group; R4 signifies -alkyl-aryl or alkyl heteroaryl;X signifies CH2, oxygen atom or sulphur atom; n is 2 or 3; including the individual (R)- and (S)-enantiomers or mixtures of enantiomers thereof; and including pharmaceutically acceptable salts and esters thereof. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.</p>
申请公布号 CA2686387(C) 申请公布日期 2015.06.30
申请号 CA20082686387 申请日期 2008.05.06
申请人 BIAL-PORTELA & CA, S.A. 发明人 SOARES DA SILVA, PATRICIO MANUEL VIEIRA ARAUJO;LEARMONTH, DAVID ALEXANDER;BELIAEV, ALEXANDER
分类号 C07D405/04;A61K31/4178;A61P25/22 主分类号 C07D405/04
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