Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2

摘要

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Uncoupling Protein 2 (UCP2), in particular, by targeting natural antisense polynucleotides of Uncoupling Protein 2 (UCP2). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of UCP2.

主权项

1. A method of upregulating a function of and/or the expression of a Uncoupling Protein 2 (UCP2) polynucleotide in patient cells or tissues in vivo or in vitro, said patient having a UCP2 associated disease or disorder, comprising:
contacting said cells or tissues with at least one antisense oligonucleotide of 12-30 nucleotides in length that specifically targets and specifically hybridizes to a region of a natural antisense oligonucleotide of the Uncoupling Protein 2 (UCP2) polynucleotide selected from SEQ ID NOS: 2 or 3; thereby upregulating a function of and/or the expression of the Uncoupling Protein 2 (UCP2) polynucleotide in patient cells or tissues in vivo or in vitro.