Conjugates for the treatment of mesothelioma

摘要

The present invention provides conjugates of cytokines and targeting peptides that is able to bind to a receptor expressed on tumor-associated vessels or to a component of the extracellular matrix associated to the tumor vessels, for treatment of malignant pleural mesothelioma. In particular, the invention provides conjugates comprising the cytokine TNF linked to a peptide containing the NGR motif. The invention further provides pharmaceutical compositions comprising such conjugate and pharmaceutical formulations comprising conjugates dissolved in appropriate buffers.

主权项

1. A method for treating mesothelioma in a patient comprising administering to a patient suffering from mesothelioma a conjugate comprising a targeting peptide and a cytokine, wherein the targeting peptide is a peptide containing a NGR motif and wherein the cytokine is TNFα.