| 发明名称 | Colon and pancreas cancer peptidomimetics | ||
| 摘要 | The invention relates to a peptidomimetic of an NPC-1 epitope on the MUC5AC protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the NPC-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods. | ||
| 申请公布号 | US9068014(B2) | 申请公布日期 | 2015.06.30 |
| 申请号 | US201113825717 | 申请日期 | 2011.09.23 |
| 申请人 | PRECISION BIOLOGICS, INC. | 发明人 | Wang Xue-Ping |
| 分类号 | C07K14/47;C07K7/08;A61K47/48;C07K16/30;G01N33/574;A61K38/00;A61K39/00 | 主分类号 | C07K14/47 |
| 代理机构 | LeClairRyan, a professional corporation | 代理人 | Teskin Robin L.;LeClairRyan, a professional corporation |
| 主权项 | 1. An isolated polypeptide comprising a polypeptide having at least 90% identity to the amino acid sequence of SX1PX2DX3FRYX4NX5 (SEQ ID NO: 1), wherein X1 is L; X2 is E or D; X3 is Y or W; X4 is T or I and X5 is Q or Y; SX1PX2DX3FRYX4NX5K (SEQ ID NO: 2), wherein X1 is L; X2 is E or D; X3 is Y or W; X4 is T or I and X5 is Q or Y; SLPDDWFRYINY (SEQ ID NO: 5); YSHSSLPDDWFRYINYGGGS (SEQ ID NO:20); or SLPDDWFRYINYSLPDDWFRYINY (SEQ ID NO:24). | ||
| 地址 | Rockville MD US | ||