<i>Flindersia </i>alkaloids, derivatives and analogs: compositions and methods for producing the same

摘要

The present invention provides methods for chemically synthesizing naturally-occurring alkaloids, for example, Flindersia alkaloids, and their analogs and derivatives. Generally, the precursor borrerine is synthesized from tryptamine in the presence of an alkylating agent, an acylating agent and a reducing agent and dimerized in the presence of an acid, for example, tetrafluoroacetic acid, hydrochloric acid or acetic acid to yield the products. Analog and derivative compounds are produced by derivatizing one or more of the tryptamine, alkylating agent or acylating agent. Also provided are the synthetic alkaloids and derivatives and analogs thereof produced by the synthetic methods.

主权项

1. A method for chemically synthesizing Flinderole A or des-methylflinderole C, comprising the steps of:
synthesizing borrerine; dimerizing said borrerine in the presence of acetic acid or hydrochloric acid, to yield a crude material; and isolating the Flinderole A or des-methylflinderole C from the crude material.