| 发明名称 | Fluorine-18 labeled rhodamine derivatives for imaging with positron emission tomography | ||
| 摘要 | The present invention is directed toward novel fluorine-18 labeled rhodamine dye derivatives and methods of making the same. The present invention is also directed toward methods of using novel fluorine-18 labeled rhodamine dye derivatives as positron emission tomography imaging agents and myocardial perfusion imaging agents. | ||
| 申请公布号 | US9066985(B2) | 申请公布日期 | 2015.06.30 |
| 申请号 | US201314101960 | 申请日期 | 2013.12.10 |
| 申请人 | Children's Medical Center Corporation | 发明人 | Packard Alan B.;Heinrich Tobias K.;Treves S. Ted;Gottumukkala Vijay |
| 分类号 | A61K49/00;A61K51/04 | 主分类号 | A61K49/00 |
| 代理机构 | Nixon Peabody LLP | 代理人 | Nixon Peabody LLP |
| 主权项 | 1. A compound comprising an 18F labeled rhodamine derivative according to formula I: wherein R1, R3, and R5 are hydrogen; R2 and R4 are alkyl; A1 is carbon or nitrogen, if A1 is nitrogen, then R6 is absent; R6 is hydrogen; R7, R8 and R9 are hydrogen; R15 is —(CH2CH2O)mCH2CH218F, wherein m is 1-50; and A- is an anion. | ||
| 地址 | Boston MA US | ||