| 主权项 |
1. A compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof, wherein:
T is —NH— or absent; each Jc1 and Jc2 is independently —CN, —F, —Cl, —OR, —CH2OR, or —CF3; each U1, U2, and U3 is independently —H, Z, or Jb wherein no more than one of U1, U2, and U3 is —H; or two of U1, U2, and U3 join together to form a C1-C6 cyloalkyl ring having 0-1 heteroatoms independently substituted with one or more Je; Z is Y2-Q2; Y2 is absent or C1-6 alkyl optionally and independently substituted with one or more Jd; Q2 is absent or C3-C8 cyloalkyl having 0-1 heteroatoms optionally and independently substituted with one or more Je, wherein Y2 and Q2 are not both absent; each Jb is independently —F, —OR, —CN, —CF3, —N(R)2, —C(O)N(R)2, C1-6 alkyl optionally and independently substituted with one or more Ja; each Ja is independently —F, —OR, —N(R)2, or —C(O)N(R)2; each Jd is independently —OR, —CN, —C(O)N(R)2, —N(R)2 or F; each Je is independently C1-C6 alkyl, —OR, —N(R)2, CF3, or F; each R is —H or C1-C6 alkyl; and wherein there is a chiral center at the carbon indicated by *, and wherein (S) represents stereochemistry on the ring carbon; with the proviso that the compound is not: |
