发明名称 |
Preparation of 5-aminosalicylic acid by gas phase catalytic carboxylation |
摘要 |
Disclosed is a process for preparing 5-aminosalicylic acid by gas phase catalytic carboxylation, characterized in that carbon dioxide is introduced into a system of p-acetaminophenol and a basic compound at a temperature of 150° C.˜220° C. and a pressure of 0.5˜5.0 MPa in the presence of a catalyst, so as to carry out a gas phase catalytic carboxylation reaction to form a 5-aminosalicylate, and the crude product 5-aminosalicylate is separated, and then acidified to prepare 5-aminosalicylic acid (5-ASA). Since the gas phase catalytic reaction replaces a solid phase thermo-chemical reaction, the reaction is significantly improved in terms of the process flow, reaction conditions, product quality and energy consumption. In addition, the reaction has a short reaction time, good selectivity, high yield and no formation of wastes during the reaction, and is suitable for industrial production. |
申请公布号 |
US9067867(B2) |
申请公布日期 |
2015.06.30 |
申请号 |
US201113997303 |
申请日期 |
2011.10.20 |
申请人 |
Zhejiang Huahai Pharmaceutical Co., Ltd.;Huazhong University Of Science And Technology |
发明人 |
Li Guangxing;Li Jinjin;Zhu Dajian;Jiang Qiang;Cai Lingli;Xie Yong;Gan Lixin |
分类号 |
C07C229/64;C07C227/18;C07C227/20;C07C231/12 |
主分类号 |
C07C229/64 |
代理机构 |
Wolf, Greenfield & Sacks, P.C. |
代理人 |
Wolf, Greenfield & Sacks, P.C. |
主权项 |
1. A process for preparing 5-aminosalicylic acid by gas phase catalytic carboxylation, comprising introducing carbon dioxide into a system of p-acetaminophenol and a basic compound in the presence of a catalyst, so as to carry out a gas phase catalytic carboxylation reaction to form a 5-aminosalicylate;
separating the crude product 5-aminosalicylate; and acidifying the crude product to prepare 5-aminosalicylic acid; wherein the catalyst is an oxide of silicon, an oxide of aluminum, or an oxide of silicon-aluminum. |
地址 |
Zhejiang CN |