Therapeutic method for mesothelioma

摘要

The present invention relates to a therapeutic method and a diagnostic method using an antibody that binds to a ganglioside GM2 antigen, and a therapeutic agent and a diagnostic agent comprising as an active ingredient an antibody that binds to a ganglioside GM2 antigen. According to the present invention, the prognosis of GM2 positive mesothelioma patients can be improved by diagnosing and treating GM2 positive mesothelioma patients with a diagnostic agent and a therapeutic agent that comprise an anti-ganglioside GM2 antibody as an active ingredient.

主权项

1. A method for treating mesothelioma, comprising administering as an active ingredient an antibody or a fragment thereof that binds to a ganglioside GM2 into a subject in need thereof,
wherein the antibody comprises heavy chain (H-chain) complementarity determining regions (CDRs) 1 to 3 having the amino acid sequences of SEQ ID NOS: 1 to 3, respectively, and light chain (L-chain) CDRs 1 to 3 having the amino acid sequences of SEQ ID NOS: 4 to 6, respectively.