Pharmacological treatment of Parkinson's disease

摘要

The present invention relates to the co-administration of two neurotransmitter agonists to patients with motor disorders, for the purpose of symptom reduction. In particular the present invention provides methods and compositions for alleviation of akinesia, rigidity and/or tremor associated with Parkinson's disease.

主权项

1. A method of treating a subject, comprising:
a) providing:
i) a serotonin type 1A (5-HT1A) receptor agonist, wherein said 5-HT1A receptor agonist is eltoprazine,ii) a dopamine receptor agonist, wherein said dopamine receptor agonist is L-DOPA, andiii) a subject receiving said dopamine receptor agonist for treating Parkinson's disease, wherein the subject is suffering from said dopamine receptor agonist-induced dyskinesia; b) co-administering the 5-HT1A agonist in combination with the dopamine receptor agonist to the subject during a preconditioning period under conditions suitable for reducing the dopamine receptor agonist-induced dyskinesia; c) co-administering the 5-HT1A agonist in combination with the dopamine receptor agonist to the subject during a dosage optimization period, wherein dosage of the dopamine receptor agonist is gradually reduced until at least one symptom of the Parkinson's disease is re-emerges; and d) co-administering the 5-HT1A agonist in combination with the dopamine receptor agonist to the subject under conditions suitable for reducing the at least one symptom of the Parkinson's disease, while reducing the dopamine receptor agonist-induced dyskinesia, wherein dosage of the dopamine receptor agonist is below that of step b and above that of step c.