GPBP-1 inhibition and its therapeutic use

摘要

The present invention provides compositions including anti-tumor agents and inhibitors of Goodpasture antigen binding protein, p21, and ABCC7, and their use in treating cancer.

主权项

1. A pharmaceutical composition, comprising:
(a) an antitumor drug or a pharmaceutically acceptable salt thereof, wherein the antitumor drug is selected from the group consisting of paclitaxel, a topoisomerase II inhibitor, 5-fluorouracil (5-FU), and cisplatin; (b) a compound of formula:or a pharmaceutically acceptable salt thereof, wherein:
R is selected from N and CR3; R1 is hydrogen or C1-C6 alkoxy; R2 is C1-C6 alkyl or halo(C1-C6 alkyl); R3, if present, is halogen, C1-C6 alkyl, or halo(C1-C6 alkyl); and R4 is H or C1-C6 alkyl; and (c) a pharmaceutically acceptable carrier.