Methods for Alzheimer's disease treatment and cognitive enhancement

摘要

The present invention relates to compositions comprising a combination of PKC activators and PKC inhibitors and methods to modulate α-secretase activity; improve or enhance cognitive ability; and/or reduce neurodegeneration in individuals suffering from diseases that impair cognitive ability, particularly Alzheimer's Disease. The invention also relates to methods for improving or enhancing cognitive ability. The present invention also provides methods for increasing the generation of non-amyloidogenic soluble APP (sAPP) comprising the activation of protein kinase C (PKC) in the brain and inhibiting PKC in peripheral tissues. Macrocyclic lactones (i.e. bryostatin class and neristatin class) are preferred PKC activators and Vitamin E is a preferred PKC inhibitor for use in the inventive composition.

主权项

1. A method for reducing neurodegeneration comprising administering to a subject in need thereof a composition comprising:
a) bryostatin-1; b) vitamin E; and c) a pharmaceutically acceptable carrier,wherein vitamin E is administered in a dose between 15 and 2,000 IU per day.