| 发明名称 | Methods for treating and/or limiting development of diabetes | ||
| 摘要 | The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes. | ||
| 申请公布号 | US9068971(B2) | 申请公布日期 | 2015.06.30 |
| 申请号 | US201314108597 | 申请日期 | 2013.12.17 |
| 申请人 | BioCrine AB | 发明人 | Berggren Per Olof;Yang Shao-Nian |
| 分类号 | A01N1/02;C12N5/00;G01N33/50 | 主分类号 | A01N1/02 |
| 代理机构 | McDonnell Boehnen Hulbert & Berghoff LLP | 代理人 | McDonnell Boehnen Hulbert & Berghoff LLP |
| 主权项 | 1. A method for identifying candidate compounds for limiting development of and/or treating diabetes, comprising a) contacting a first population of insulin secreting cells with an amount of ApoCIII effective to increase density and/or conductivity of Cav1 channels, in the presence of one or more test compounds; and b) identifying those positive test compounds that inhibit the ApoCIII-induced increase in density and/or conductivity of Cav1 channels and that inhibit SRBI expression or activity in the first population of insulin secreting cells compared to control, wherein the control comprises contacting a second population of insulin secreting cells with an amount of ApoCIII effective to increase density and/or conductivity of Cav1 channels, in the absence of test compounds; wherein the positive test compounds are candidate compounds for limiting development of and/or treating diabetes. | ||
| 地址 | Stockholm SE | ||