Peptidic antigen that induces antibody recognizing three-dimensional structure of HIV and method for synthesizing same

摘要

An object of the present invention is to provide an HIV antibody-inducing peptide antigen that is effective in developing an antibody or a vaccine having specificity and binding activity for the three-dimensional structure of a neutralization target, i.e. the mechanism by which HIV invades a target cell; a method for synthesizing the same; a vaccine comprising the peptide antigen, or an HIV three-dimensional structure-recognizing antibody induced by the peptide antigen; and a preventive and/or therapeutic agent for HIV infection comprising the peptide antigen, the vaccine, or the HIV three-dimensional structure-recognizing antibody as an active ingredient.

主权项

1. A peptide antigen capable of inducing an HIV three-dimensional structure-recognizing antibody that recognizes a trimer region of a N-terminal helical region of an HIV particle transmembrane protein gp41 (N36), wherein the peptide antigen comprises: a trimer of N36 peptide derivatives comprising three N36 peptide derivatives ligated to a C3-symmetric template compound having three equivalent linker structures, wherein each N36 peptide derivatives comprises SEQ ID NO: 1; and wherein the C3-symmetric template compound having three equivalent linker structures is the compound of formula (1): (wherein X represents a positive integer).