| 发明名称 |
ANTI-CANCER ACTIVITY OF CYTOTOXIC POLYPEPTIDES FROM MALAYSIAN ISOLATES OF BACILLUS THURINGIENSIS |
| 摘要 |
<p>THE PRESENT INVENTION RELATES TO PARASPORAL INCLUSIONS KNOWN AS 8-ENDOTOXIN PRODUCED BY BACILLUS THURINGIENSIS AND WHICH HAS CYTOTOXIC ACTIVITY AGAINST CANCER CELLS. MORE PARTICULARLY, THE PRESENT INVENTION RELATES TO A NON-HAEMOLYTIC BACILLUS THURINGIENSIS PARASPORAL INCLUSIONS WHICH CAN PREFERENTIALLY KILL LEUKEMIC CELL LINES. THE PARASPORAL INCLUSIONS OF THE PRESENT INVENTION ARE ENCODED BY A FAMILY OF CRY AND CYT GENES AND SHOW SELECTIVE THERAPEUTIC SPECIFICITY FOR CEM-SS CELL LINES AND ARE NON-CYTOTOXIC TO NORMAL T LYMPHOCYTES.</p> |
| 申请公布号 |
MY154497(A) |
申请公布日期 |
2015.06.30 |
| 申请号 |
MY2009PI03257 |
申请日期 |
2009.08.06 |
| 申请人 |
INSTITUTE FOR MEDICAL RESEARCH, MALAYSIA |
发明人 |
DR. LEE HAN LIM;SELEENA POORANI BENJAMIN;DR. VISHNA DEVI A/P V NADARAJAH |
| 分类号 |
C07K14/325 |
主分类号 |
C07K14/325 |
| 代理机构 |
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代理人 |
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