Pharmaceutical composition for the treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases

摘要

Provided is a pharmaceutical composition for the treatment and prevention of obesity, diabetes, metabolic syndromes, degenerative diseases and mitochondrial dysfunction-related diseases, comprising: a therapeutically effective amount of a compound represented by Formula I below, or a pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, and a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof.;wherein R1 through R8 and n are as defined in this disclosure.

主权项

1. A method of treating a liver disease, comprising
administering to a subject in need thereof a pharmaceutical composition comprising: (a) a therapeutically effective amount of a compound represented by Formula I: wherein R1 and R2 are each independently hydrogen, halogen, alkoxy, hydroxy or lower alkyl having 1 to 6 carbon atoms; R3, R4, R5, R6, R7 and R8 are each independently hydrogen, hydroxy, C1-C20 alkyl, alkene or alkoxy, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, or two substituents of R3 to R8 may be taken together to form a cyclic structure; and n is 0 or 1, with proviso that when n is 0, carbon atoms adjacent to n form a cyclic structure via a direct bond; or a pharmaceutically acceptable salt thereof, and (b) a pharmaceutically acceptable carrier, a diluent or an excipient, or any combination thereof, wherein the liver disease is selected from the group consisting of a fatty liver, hepatic failure, liver function failure, and hepatomegaly.