发明名称 |
Methods of making l-ornithine phenyl acetate |
摘要 |
<p>Disclosed is a process for making L-ornithine phenyl acetate salt (V) comprising: preparing a solution of phenyl acetate salt by mixing a phenyl acetic acid and a base in a solvent; intermixing L-ornithine benzoate with the above solution; isolating a composition comprising L-ornithine phenyl acetate. The process may include forming an L-ornithine benzoate salt intermediate. The process may also include intermixing a halide salt of L-ornithine with silver phenyl acetate. The present application also relates to various compositions obtained from these processes, including crystalline forms.</p> |
申请公布号 |
NZ609191(A) |
申请公布日期 |
2015.06.26 |
申请号 |
NZ20110609191 |
申请日期 |
2011.10.05 |
申请人 |
OCERA THERAPEUTICS INC. |
发明人 |
ANDERSON KEITH H.;BEHLING JIM;DOUGAN CHRISTINE HENDERSON;WATT STEPHEN WILLIAM;MANINI PETER;FIGINI ATTILIA |
分类号 |
C07C227/18;A61K31/192;A61K31/198;A61P1/16;C01G5/00;C07C57/32;C07C57/46;C07C229/26 |
主分类号 |
C07C227/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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