Gram-positive bacteria specific binding compounds

摘要

Disclosed is an antibody or a functional part thereof that binds to a serine-aspartate (SD) repeat dependent epitope on a SD repeat (SDR) protein expressed by a Staphylococcus species, wherein the antibody or functional part thereof is coupled to a cytotoxic agent to form an antibody-drug conjugate. Also disclosed is the use of the disclosed antibody-drug conjugate in the preparation of a medicament and/or prophylactic agent for treating and/or preventing a Gram-positive bacterium-related disorder in an individual.