New cyclohexylamine derivatives having &bgr;2 adrenergic agonist and m3 muscarinic antagonist activities

摘要

Disclosed are cyclohexylamine compounds of formula (A) having &bgr;2 adrenergic agonist and M3 muscarinic antagonist dual activity, wherein the substituents are as defined in the specification. Also disclosed is the use of compounds of formula (A) as bronchodilator agents for the treatment of respiratory disorders such as COPD and asthma. An example of a compound of formula (A) is: Trans-4-[{ 3-[6-({ [(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino} methyl)-2-oxo-1,3-benzoxazol-3(2H)-yl]propyl} (methyl)amino]-cyclohexyl hydroxy(di-2-thienyl)acetate dihydrofluoride