| 摘要 |
<p>The present invention relates to process for the preparation of Flecainide acetate (I) comprising reaction of 2,5-bis (2,2,2-trifluoroethoxy)benzoic acid with 1,1'-carbonyldrimidazole (CD1) to give (2,5-diethoxy-phenyl)-imidazol-l-yl-methanone, which on coupling with 2-aminomethylpyridine in presence of a base gave N-(2-pyridinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide, further treatment with hydrochloric acid gave N-(2-pyridinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy) benzamide HC1 salt which on hydrogenation in the presence of a catalyst gave Flecainide, further treatment with acetic acid gave Flecainide acetate (I) of desired purity.</p> |
