APTAMERS SPECIFIC FOR BETACASOMORPHIN7 (BCM7)

摘要

Abstract Fifteen apta~nersa gainst betacasomorphin7 (BCM7) are selected employii~gS ELEX. These aptamers have different structural motif or G-quadruplex or other features. The dissociatiol~ constants of aptamer-BCM7 are in nanoinolar range indicating their higher affinity for target. I'he aptamers can be used as recognition eleinents for developing methods for detection of BCM7 in urine and blood as well as for ascertaining whether milk is A1 or A2 in nature. These aytamers call also be used as therapeutic agent for overcomil~gil l effect of BCM7. r' Director, J National Dairy Research Institute (Indian Council of Agricultural Research) Krishi Bhawan, New Delhi-110001, India Cirarctor x''iond Dairy Rr,sa3nrch ~ns+ihl+r Kar~d-132001O -InqrRnn)