CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS

摘要

Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

主权项

1. A compound of Formula (I) having the structure: wherein: A is a carboxylic acid isostere; X is CR1, or N; R1 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R2 and R3 are each independently H, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl; or R2 and R3 together with the carbon to which they are attached form a cycloalkyl or heterocycloalkyl ring; or a pharmaceutically acceptable salt, solvate, or prodrug thereof.