| 发明名称 |
Genetically Engineered Torulopsis glabrata with Enhanced Extracellular Secretion of Pyruvic Acid |
| 摘要 |
The present invention provides a genetically engineered Torulopsis glabrata with enhanced extracellular secretion of pyruvic acid. T. glabrata strain was obtained from China Center for Type Culture Collection with CCTCC No: M202019 and over-expressed the optimized CutA (SEQ ID NO:2) encoding stress protein. Both of the temperature tolerance of T. glabrata and extracellular concentration of pyruvate were improved by overexpressing the optimized CutA. The optimum growth temperature of genetically engineered T. glabrata was increased too. The present invention can be widely used to increase extracellular levels of pyruvate during the fermentation process. |
| 申请公布号 |
US2015176036(A1) |
申请公布日期 |
2015.06.25 |
| 申请号 |
US201414185928 |
申请日期 |
2014.02.21 |
| 申请人 |
Chen Jian;Guo Hongwei;Zhou Jingwen;Du Guocheng |
发明人 |
Chen Jian;Guo Hongwei;Zhou Jingwen;Du Guocheng |
| 分类号 |
C12P7/40;C12N15/81 |
主分类号 |
C12P7/40 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A genetically engineered Torulopsis glabrata (T. glabrata) strain with enhanced extracellular secretion of pyruvic acid, wherein said T. glabrata strain is obtained from China Center for Type Culture Collection with CCICC No: M202019 and over-expresses CutA encoding stress protein. |
| 地址 |
Wuxi CN |
