DIAGNOSIS AND PROGNOSIS OF HIGH HYPERDIPLOID ACUTE LYMPHOBLASTIC LEUKEMIA

摘要

The present invention provides a method for the diagnosis or prognosis of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH-ALL) in a patient, comprising providing a sample from a patient; carrying out simultaneous iFISH with chromosome specific probes labeled with fluorophores of different colors; determining the gain of the labeled chromosomes in every cells; and diagnosing the patient for the presence of HeH-ALL if the incidence of the possible chromosome gain combinations has the predetermined ratio.