| 发明名称 |
COMPOSITIONS AND METHODS FOR MODULATING HBV EXPRESSION |
| 摘要 |
Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine. |
| 申请公布号 |
US2015176007(A1) |
申请公布日期 |
2015.06.25 |
| 申请号 |
US201514633491 |
申请日期 |
2015.02.27 |
| 申请人 |
ISIS PHARMACEUTICALS, INC. |
发明人 |
Prakash Thazha P.;Seth Punit P.;Swayze Eric E. |
| 分类号 |
C12N15/113;C07H21/04 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound comprising a modified oligonucleotide and a conjugate group, wherein the modified oligonucleotide consists of 12 to 30 linked nucleosides and comprises a nucleobase sequence comprising a portion of at least 8 contiguous nucleobases complementary to an equal length portion of nucleobases 1583 to 1602 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is at least 80% complementary to SEQ ID NO: 1; and wherein the conjugate group comprises: |
| 地址 |
Carlsbad CA US |
