| 摘要 |
The present invention provides a therapeutic agent for epithelial and endothelial injury, and in particular, for epithelial and endothelial microinjury, and the like. The therapeutic agent according to the present invention comprises, for example, a peptide of the following (a), (b), etc., a derivative thereof, or their salt: (a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; or (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22. |
| 主权项 |
1. A peptide of any one of the following (a) to (f), a derivative thereof, or their salt:
(a) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 10, 4, 12 and 6; (b) a peptide comprising the amino acid sequence shown in any one of SEQ ID NOS: 16, 18, 20 and 22; (c) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells; (d) a peptide, which comprises an amino acid sequence having a deletion, substitution or addition of one or several amino acids with respect to the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells; (e) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 10, 4, 12 and 6, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells; and (f) a peptide, which comprises an amino acid sequence having homology of 80% or more with the amino acid sequence shown in any one of 16, 18, 20 and 22, and which has an activity of repairing epithelial and endothelial injury or an activity of inducing spread of epithelial and endothelial cells. |
