| 发明名称 |
GENERATING HEPATOCYTES |
| 摘要 |
Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein. |
| 申请公布号 |
US2015175962(A1) |
申请公布日期 |
2015.06.25 |
| 申请号 |
US201414578377 |
申请日期 |
2014.12.20 |
| 申请人 |
Zhu Saiyong;Ding Sheng;Willenbring Holger;Rezvani Milad;Harbell Jack |
发明人 |
Zhu Saiyong;Ding Sheng;Willenbring Holger;Rezvani Milad;Harbell Jack |
| 分类号 |
C12N5/071;A61K35/12;A61K31/506;A61K38/17;A61K38/20;A61K31/19;A61K31/135;A61K31/405;A61K31/4709;A61K31/573;A61K38/18;A61K31/661 |
主分类号 |
C12N5/071 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising an epidermal growth factor (EGF), a basic fibroblast growth factor (bFGF), an activator of WNT signaling, a nuclear receptor liver receptor homolog 1 agonist, a histone deacetylase (HDAC) inhibitor, a histone demethylase LSD1 inhibitor, a DNA methyltransferase (DNMT) inhibitor, or any a combination thereof. |
| 地址 |
San Francisco CA US |
