发明名称 |
METHOD FOR THE SYNTHESIS OF N-(PHOSPHONOMETHYL)GLYCINE |
摘要 |
A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters, or its phosphonate ester salts, which includes the steps of: a) forming, in the presence an acid catalyst, a reaction mixture having 2,5-diketopiperazine, formaldehyde and a compound including one or more P-0-P anhydride moieties, the moieties having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bisphosphonomethyl-2,5-diketopiperazine, its mono- to tetra phosphonate esters, the dehydrated forms of N,N′-bisphosphonomethyl-2,5-diketopiperazine and the phosphonate esters of its dehydrated forms; and b) hydrolysing the N,N′-bisphosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters to obtain N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts. |
申请公布号 |
US2015175636(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
US201314415690 |
申请日期 |
2013.07.17 |
申请人 |
STRAITMARK HOLDING AG |
发明人 |
Burck Sebastian;Bruyneel Frederic;Notte Patrick |
分类号 |
C07F9/38;C12P13/04 |
主分类号 |
C07F9/38 |
代理机构 |
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代理人 |
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主权项 |
1. A method for the synthesis of N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts, comprising the steps of:
a) forming, in the presence of an acid catalyst, a reaction mixture comprising 2,5-diketopiperazine, formaldehyde and a compound comprising one or more P-O-P anhydride moieties, said moieties having one P atom at the oxidation state (+III) and the other P atom at the oxidation state (+III) or (+V), to form N,N′-bisphosphonomethyl-2,5-diketopiperazine, its mono to tetra phosphonate esters, the dehydrated forms of N,N′-bisphosphonomethyl-2,5-diketopiperazine and the phosphonate esters of its dehydrated forms; and b) hydrolysing said N,N′-bisphosphonomethyl-2,5-diketopiperazine, its dehydrated forms or their phosphonate esters to obtain N-(phosphonomethyl)glycine or one of its derivatives selected from the group consisting of its salts, its phosphonate esters and its phosphonate ester salts. |
地址 |
Zug CH |