发明名称 |
ALPHA-ENOLASE SPECIFIC ANTIBODIES AND METHODS OF USES IN CANCER THERAPY |
摘要 |
The present invention discloses an anti-human alpha-enolase (ENO1) antibody, which can bind the peptides, comprising amino-acid sequence 296FD Q D D W G A W Q K F TA309 (SEQ ID: #9 ) and/or 326K R I A K A V N EK S336 (SEQ ID: #10 ) of human ENOl protein (GenBank: AAH50642.1), has a favorable binding activity (the binding affinity is around 2.19 x 10-10 mol/L) and a remarkable capability to inhibit the cell invasion and tumor metastasis of a varied of tumors. The recognized peptides and antibody of the invention are useful for diagnosis, prognosis, and treatment of cancers that have been reported to express cell-surface ENO1 such as including lung, breast, pancreas, liver, colorectal, prostate cancers and solid tumors. |
申请公布号 |
WO2015094330(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
WO2013US76877 |
申请日期 |
2013.12.20 |
申请人 |
DEVELOPMENT CENTER FOR BIOTECHNOLOGY;NATIONAL HEALTH RESEARCH INSTITUTES;DCB-USA LLC |
发明人 |
TSAI, SHIH-CHONG;SHIH, NENG-YAO;YUAN, TA-TUNG;LIU, KO-JIUNN;TSENG, SHIH-CHI;HU, CHIH-YUNG;WANG, HSIN-YUN;CHEN, LI-TZONG |
分类号 |
C07K16/40;A61K39/395;A61P35/00 |
主分类号 |
C07K16/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|