SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR CONTROLLING EXPRESSION OF TGF-Β1 GENE

摘要

　The present invention provides a single-stranded nucleic acid molecule for inhibiting the expression of the TGF-β1 gene, said molecule being characterized by comprising only a region (X), a linker region (Lx) and a region (Xc), wherein the linker region (Lx) has a non-nucleotide structure containing a pyrrolidine skeleton and/or a piperidine skeleton, and at least one of the region (X) and the region (Xc) includes an expression-inhibiting sequence that inhibits the expression of the TGF-β1 gene. The present invention further provides a therapeutic pharmaceutical composition for pulmonary fibrosis or acute lung injury that contains the single-stranded nucleic acid molecule.