COMPOSITIONS AND METHODS FOR ATMOSPHERIC SPRAY FREEZE DRYING

摘要

Methods of preparing dried powders of biologically active compositions are disclosed. They are designed to provide dried material that maintains biological activity at low economic cost. Compositions made by the above methods are also described.

主权项

1. A method of preparing a powder, comprising the steps of:
a. spraying a carrier liquid into a chamber to form a flow of liquid droplets, wherein the carrier liquid contains a powder-forming ingredient; b. freezing the liquid droplets into frozen particles; c. entraining the flow of frozen particles within a net flow of gas of less than about 8 SCFM, the flow of gas entering the chamber around the flow of frozen particles to prevent the frozen particles from accumulating on the walls of the chamber; d. collecting the frozen particles on a filter; and e. drying the frozen particles by passing a flow of gas downward through the frozen particles at a rate of greater than about 16 SCFM to remove the carrier liquid; and f. forming a dry powder.