| 发明名称 |
IgA CD4i ANTIBODIES AND METHODS OF TREATMENT USING SAME |
| 摘要 |
The present invention relates to isolated IgA antibodies, or fragments thereof, which have variable domains derived from an antibody that specifically binds to a CD4-induced (CD4i) epitope. In particular, the isolated IgA antibodies display enhanced neutralization activity relative to their IgG, non-chimeric counterparts. The invention also provides methods for therapy with the isolated IgA antibodies for the treatment of a subject having a viral infection or having an increased risk of a viral infection. |
| 申请公布号 |
US2015175678(A1) |
申请公布日期 |
2015.06.25 |
| 申请号 |
US201314408182 |
申请日期 |
2013.06.17 |
| 申请人 |
Beth Israel Deaconess Medical Center, Inc. |
发明人 |
Cavacini Lisa;Posner Marshall;Yu Xiaocong |
| 分类号 |
C07K16/10;A61K47/48;A61K39/42 |
主分类号 |
C07K16/10 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated IgA antibody, or fragment thereof, wherein the variable domains of the IgA antibody are derived from an antibody that specifically binds to a CD4-induced (CD4i) epitope of a polypeptide. |
| 地址 |
Boston MA US |
