发明名称 |
Process for Producing Self-Assembling Peptide Derivatives |
摘要 |
An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt. |
申请公布号 |
US2015175663(A1) |
申请公布日期 |
2015.06.25 |
申请号 |
US201314412190 |
申请日期 |
2013.07.12 |
申请人 |
MENICON CO., LTD. ;NAGASE & CO., LTD. ;NAGASE CHEMTEX CORPORATION |
发明人 |
Yokoi Hidenori;Yokoyama Yasuhiro;Matsuyama Keisuke;Yamamoto Kenichiro;Anzai Kinsei;Nakamura Daisuke;Nagano Toyohiro;Kodama Kazuya |
分类号 |
C07K7/08;C07K7/06 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
|
主权项 |
1. A disulfuric acid salt of a peptide derivative, represented by general formula (IX):Ac-Arg-Leu-Asp-Leu-Arg-Leu-Ala-Leu-Arg-Leu-Asp-Leu-Arg-NH2•2H2SO4 or general formula (X):Ac-Arg-Leu-Asp-Leu-Arg-Leu-Leu-Leu-Arg-Leu-Asp-Leu-Arg-NH2•2H2SO4. |
地址 |
Nagoya-shi JP |